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Lactate production is a prioritized feature of adipocyte metabolism.
Krycer JR, Quek LE, Francis D, Fazakerley DJ, Elkington SD, Diaz-Vegas A, Cooke KC, Weiss FC, Duan X, Kurdyukov S, Zhou PX, Tambar UK, Hirayama A, Ikeda S, Kamei Y, Soga T, Cooney GJ, James DE. Krycer JR, et al. Among authors: weiss fc. J Biol Chem. 2020 Jan 3;295(1):83-98. doi: 10.1074/jbc.RA119.011178. Epub 2019 Nov 5. J Biol Chem. 2020. PMID: 31690627 Free PMC article.
Insulin signaling requires glucose to promote lipid anabolism in adipocytes.
Krycer JR, Quek LE, Francis D, Zadoorian A, Weiss FC, Cooke KC, Nelson ME, Diaz-Vegas A, Humphrey SJ, Scalzo R, Hirayama A, Ikeda S, Shoji F, Suzuki K, Huynh K, Giles C, Varney B, Nagarajan SR, Hoy AJ, Soga T, Meikle PJ, Cooney GJ, Fazakerley DJ, James DE. Krycer JR, et al. Among authors: weiss fc. J Biol Chem. 2020 Sep 18;295(38):13250-13266. doi: 10.1074/jbc.RA120.014907. Epub 2020 Jul 28. J Biol Chem. 2020. PMID: 32723868 Free PMC article.
Systems-level analysis of insulin action in mouse strains provides insight into tissue- and pathway-specific interactions that drive insulin resistance.
Nelson ME, Madsen S, Cooke KC, Fritzen AM, Thorius IH, Masson SWC, Carroll L, Weiss FC, Seldin MM, Potter M, Hocking SL, Fazakerley DJ, Brandon AE, Thillainadesan S, Senior AM, Cooney GJ, Stöckli J, James DE. Nelson ME, et al. Among authors: weiss fc. Cell Metab. 2022 Feb 1;34(2):227-239.e6. doi: 10.1016/j.cmet.2021.12.013. Epub 2022 Jan 11. Cell Metab. 2022. PMID: 35021042 Free article.